Founding Engineer

at Astraea — AI Operating System for Clinical Development

San Francisco, CA, USFull-time1+ years$120K - $220K0.50% - 2.00% equityYC-S26

What the role involves

We are looking for a founding engineer who wants to build deeply technical AI systems in one of the most important and regulated industries in the world.

You will work directly with the founders to

  • Build agentic workflows for clinical trial automation
  • Design reliable systems for document ingestion, data transformation, validation, and auditability
  • Own core product surfaces across frontend, backend, data infrastructure, and AI orchestration
  • Work closely with clinical teams to turn messy real-world workflows into production software
  • Ship quickly while maintaining the rigor required for regulated healthcare environments

You might be a fit if you

  • Are an exceptional full-stack or backend engineer
  • Care about building reliable, production-grade AI systems and can/have integrated into legacy systems in the past
  • Move fast, take ownership, and like ambiguous technical problems
  • Are excited by using AI to automate healthcare, clinical trials, or regulated data workflows
  • Want to join at the earliest stage and help define the engineering culture

We care less about credentials and more about raw ability, taste, speed, and ownership. This is a high-agency founding role for someone who wants to build category-defining software.

What they ask for

ReactTypeScriptPrompt EngineeringAI AgentsLangChain

About Astraea

Astraea automates clinical trial biometrics from raw study inputs to FDA-ready outputs. The platform handles data normalization, CDISC mapping, SDTM, ADaM, TFLs, QC, and revision workflows in one auditable system, helping Phase II/III sponsors reduce months of manual programming and data management into automated, reviewable execution.

Full Astraea profile

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